Methionine restriction and cancer treatment: a systems biology study of yeast to investigate the possible key players

Background/aim: Dietary restriction, mainly carbon and/or methionine restriction are among the upcoming supporting interventions along with chemotherapy in various cancers. Although dietary has been proven to be beneficial, main cellular machineries affected by its administration lacks deeper information considerably, a notable pitfall use as personalized nutritional approach. Materials and methods: In this study, effects of on yeast model explored via systems biology approaches. The biosynthesis network, constructed integrating interaction data gene ontology terms, was analysed topologically, proved informative about intertwined relationship cancer. Experimentally, were vivo, transcriptome analyses. Results: integrative analysis transcriptional together reconstructed network gave insight into such TOR, MAPK, sphingolipid-mediated signaling cascades mostly responsive pathways methioninerestricted cases Sch9p (functional orthologue mammalian S6 kinase) being placed at intersection these routes.